Book your stay on our website
and save up to 10%
compared to Booking.com!
Check rooms and rates
From82US$ /night
Check-in
11Dec2025Select date
Check-out
12Dec2025Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

Via Cola Di Rienzo 23, Rome, Italy, 00192
-
Close to Piazza di Spagna
Perfect
8.3
8.1
/10
3.6
3.7
/5

Location

Hotel Twentyone is situated in the Prati district, conveniently located between the Vatican Museums and Piazza di Spagna. Guests can reach several key attractions on foot, including the Trevi Fountain and Piazza Navona. The nearby Lepanto underground station allows quick transport to Rome's best shopping streets and cultural spots.

Rooms

The hotel offers 93 stylish rooms, each featuring custom-made furnishings and artistic decor. Deluxe double rooms on the fifth floor include private terraces with views of iconic landmarks. Junior suites provide additional luxury with spacious layouts and their own Jacuzzis.

Dining

Bistro 21 serves traditional Italian cuisine made from top-quality ingredients, ensuring a remarkable dining experience. Guests can enjoy a rich buffet lunch or visit for an aperitif with a variety of cocktails. The restaurant's menu frequently changes, offering seasonal Italian specialties.

Family Amenities

Hotel Twentyone accommodates families with convenient room options, including two connected rooms for more space and privacy. Each room is equipped with modern amenities to cater to family needs. The hotel's central location allows families easy access to popular attractions for all ages.

Business Facilities

The hotel provides 24-hour reception and efficient check-in services for business travelers. Meeting and event spaces are available to host work-related gatherings. Hotel Twentyone's proximity to key business areas and transit options enhances connectivity for corporate guests.

Highlights

Location: halfway between St Peter's and the Spanish Steps

Rooms: Junior suites each with Jacuzzi

Dining: Bistro 21 serves traditional Italian cuisine

Family Amenities: Two rooms connected by a door

“In my opinion, this hotel's location between the Vatican and Spanish Steps strikes a smart balance for exploring Rome. I noted the rooftop restaurant, which gives the hotel a genuine advantage, providing unique panoramic views. While some rooms apparently lack the promised balconies, the proactive housekeeping hints at a commitment to guest comfort.”
Hotel logo
James DavidEditor-in-Chief at Familyhotels
View all

Choose from a variety of room types

Choose from a wide variety of rooms designed for families, including double rooms, family suites, and rooms with breakfast included
Twin Room
2 persons
18 m² 
2 Single beds
Shower
Heating
Triple Room
2 persons
22 m² 
3 Single beds
Shower
Heating
Double Room
2 persons
18 m² 
1 King-size bed
Shower
Heating
Deluxe Twin Room
2 persons
23 m² 
2 Single beds
Shower
Heating
Click button to see more rooms
Show all rooms
Show all roomsLess

Availability and pricing for your selected dates

Book your family’s getaway in a snap with up-to-date availability and pricing!

Facilities

Each family-friendly hotel provides top-notch amenities for an unforgettable stay with your loved ones

General

  • Non-smoking rooms
  • Free Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • No pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Allergy-free rooms
  • Lift
  • Barber shop
  • Coffee shop
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers
  • Key card access

Sports & Fitness

  • Fitness centre

Services

  • Paid airport shuttle
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Tours/Ticket assistance
  • Welcome drink

Dining

  • In-room breakfast
  • Restaurant
  • Snack bar
  • Bar/ Lounge area
  • Packed lunches
  • Special diet menus

Business

  • Fax/Photocopying

Children

  • Cots
  • Children's buffet

Facilities for people with disabilities

  • Toilet for disabled
  • Bathroom for disabled

Spa & Leisure

  • Garden area
  • Leisure/ TV room

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Sitting area
  • Terrace
  • Garden furniture
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries
  • Sink

Media

  • Flat-screen TV
  • AM/FM alarm clock

Room decor

  • Carpeted floor
Show more

Dining Onsite

At the Twentyone Hotel, dining options celebrate the essence of international flavors while embracing local traditions. Guests can indulge in a vibrant buffet with traditional Roman and classic Italian specialties, paired with an impressive selection of wines and celebratory champagnes, all within a modern and inviting setting.
Twentyone Hotel Rome Restaurant photo
Twentyone Hotel Rome Restaurant photo
Twentyone Hotel Rome Restaurant photo

Vista

International and Italian
Ambiance
Modern and inviting, perfect for both leisurely meals and special gatherings.
Key Offerings
A delightful buffet brimming with traditional Roman and Italian dishes, accompanied by a diverse array of wines and champagne.
Reservation
Not needed unless for large groups.
Open daily from 11:30 to 23:30.

Location

Via Cola Di Rienzo 23, Rome, Italy, 00192
Map view
Via Cola Di Rienzo 23, Rome, Italy, 00192
Nearby
Bridge
Castel Sant'Angelo
1.1 km
Square
Piazza del Popolo
740 m
Bridge
St. Angelo Bridge
1.1 km
Church
Church of Santa Maria del Popolo
690 m
Church
Basilica of Sant' Agostino
1.0 km
Restaurants
Bistro' 21
30 m
Via Cola di Rienzo 23 Hotel Twenty One
Cantieri Bistrot
90 m
Via Cola di Rienzo 16
Le Sicilianedde
80 m
Via Cola di Rienzo
La Pinseria Prati
80 m
Via Lucrezio Caro 60
Pasticceria Sanzini
130 m
Via Valadier
VINO e FOCACCIA
140 m
Piazza Cola di Rienzo 83/A
Grotta Azzurra
210 m
Via Cicerone 62a
Quelli del bar Cicerone
170 m
Via Cicerone 68
Ristorante Visconti 2.0
220 m
Via Ennio Quirino Visconti 83
Explore Rome
Activities, Dining & Entertainment Near Twentyone Hotel
Top Attractions
Activities
Dining
Entertainment
Piazza Navona
Piazza Navona
16-minute walk
Famous for its stunning fountains and vibrant atmosphere, featuring artists, cafes, and gelato shops.
Castel Sant'Angelo
Castel Sant'Angelo
13-minute walk
Historical castle with panoramic views of Rome. Explore its museum and gardens on your visit.
Vatican Museums
Vatican Museums
20-minute walk
Home to priceless art collections, including the Sistine Chapel. Booking in advance is recommended.
St. Peter's Basilica
St. Peter's Basilica
20-minute walk
Stunning Renaissance architecture, famous for Michelangelo's dome. Free entry but guided tours available.
Tiber Island Stroll
25-minute walk
Leisure walk across Tiber Island with lovely views of the river and nearby historical sites.
Roman Bike Tour
20-minute drive
Thrilling bike tour exploring ancient Rome's streets. Rentals and guided options available.
Bistro' 21
Bistro' 21
1-minute walk
Casual eatery serving traditional Italian dishes with a cozy ambiance. Reservations recommended during peak hours.
Cantieri Bistrot
Cantieri Bistrot
2-minute walk
Charming bistro with a mix of Italian and Mediterranean flavors. Great for lunch or a relaxing dinner.
Teatro Olimpico
10-minute drive
Renowned for hosting concerts and cultural events. Check the schedule for upcoming shows.
Piazza del Popolo
Piazza del Popolo
9-minute walk
Vibrant square known for live performances and events. A great place to unwind and enjoy the atmosphere.
Tips on navigating the city
City Centre
Rome28 min  ·  2.3 km
Airports
Rome Ciampino Airport (CIA)28 min  ·  18.6 km
Roma-Fiumicino Airport (FCO)45 min  ·  29.6 km
Train
Roma San Pietro Train Station23 min  ·  1.9 km
Underground
Lepanto Metro Station5 min  ·  400 m
Get access to exclusive early booking discounts for your family’s upcoming getaway
Book now and enjoy exclusive rates on your family vacation!
Check Rates
Property information and rules
Check-in
from 15:00-23:59
Check-out
from 07:00-11:00
Guest Parking
Private parking is possible on site (reservation might be needed) at EUR 35 per day.
Internet
is available in for free.
Breakfast
The hotel Twentyone provides visitors with a free full breakfast. 
Children & extra beds
There are no cots provided in a room. 
Pets
Pets are not allowed.
Languages
English, German, Spanish, Italian, Russian, Moldovan
Year renovated:
2009
Number of floors:
6
Number of rooms:
88
FAQs
About Twentyone Hotel
What is the check-in and check-out policy at Twentyone Hotel?
Check-in is at 15:00 and check-out is by 11:00.
Is there an airport transfer service available at Twentyone Hotel?
The hotel offers paid airport shuttle services for guest convenience.
What amenities are included in the rooms at Twentyone Hotel?
Rooms feature air conditioning, free Wi-Fi, an LCD satellite TV, a minibar, and coffee/tea making facilities.
How far is Twentyone Hotel from the Vatican?
The hotel is a 15-minute walk from the Vatican and Saint Peter's Basilica.
What dining options are available at Twentyone Hotel?
The on-site restaurant serves traditional Roman and classic Italian dishes, and a breakfast buffet is available for an additional charge.
Is there parking available at Twentyone Hotel?
Private parking is available on-site for 35 EUR per day, with reservation needed.
What are some popular nearby attractions to Twentyone Hotel?
Nearby attractions include Piazza Navona (1 km), Colosseum (3 km), and Castel Sant'Angelo (1 km).
Does Twentyone Hotel offer any fitness facilities?
Guests can work out at the hotel's fitness center.
What languages are spoken by the staff at Twentyone Hotel?
The staff speaks multiple languages to assist their guests effectively.
What is the distance from Twentyone Hotel to Roma Termini train station?
The hotel is 3 km from Roma Termini train station.
Where can I find local dining options near Twentyone Hotel?
Local dining options within 0.5 km include Gelateria La Romana, Il Piccolo Diavolo, and Pizza Dai Cinque.
Is Wi-Fi available at Twentyone Hotel?
Free Wi-Fi is available throughout the hotel.
What type of hotel is Twentyone Hotel?
It is a modern boutique hotel located in the elegant Prati district, ideal for leisure and business travelers.

Next best alternative

Consider them for your next trip.
Check-in
11Dec2025Select date
Check-out
12Dec2025Select date
Rooms and Guests2 Guests, 1 Room
Need more options?
Check Top hotels near Twentyone Hotel
Sogno Di Un'Epoca Hotel Rome Exterior photo
Mobile-only price

Sogno Di Un'Epoca Hotel Rome

8.7
Great133 reviews
62m from property
USD 218USD 196
per night
Glamour Center Of Rome B&B Exterior photo
Mobile-only price

Glamour Center Of Rome B&B

8.9
Great289 reviews
136m from property
USD 108USD 97
per night
Hotel Casa Valdese Roma Exterior photo
Mobile-only price

Hotel Casa Valdese Roma

8.3
Great1386 reviews
195m from property
USD 89USD 80
per night